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KMID : 1134820070360070825
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 7 p.825 ~ p.831
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Anti?Proliferation Effects of Decursin from Angelica gigas Nakai in the MCF?7 Cells Treated with Environmental Hormones
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Park Kyung-wuk
Choi Sa-Ra
Yang Hee-Sun
Cho Hyun-Wook
Kang Kap-Suk
Seo Kwon-Il
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Abstract
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Anti-proliferation effects of decursin from Angelica gigas Nakai were investigated in the MCF-7 cells treated with environmental hormones. The proliferation was decreased in a dose-dependent manner at the concentration over 20 ㎍/mL in the MCF-7 cells treated with decursin of various concentrations. The environmental hormones such as 17β-estradiol and bisphenol increased the growth of MCF-7 cells in the charcoal-treated FBS (cFBS) medium and the proliferation was the highest at 0.1 ㎛ among the tested hormone concentration. Decursin was predicted to inhibit the proliferation in a dose-dependent fashion at tested concentrations (1, 3, 10 or 30 ㎍/mL) in the MCF-7 cells added environmental hormones; however, the survival rate of the cells was lower than that of control cells that were not treated with decursin at 30 ㎍/mL concentration. The chromatin condensation and apoptotic body were examined in the decursin treated cells cultured with the cFBS medium added environmental hormones. These results suggest that decursin decreased the proliferation through apoptosis in the MCF-7 cells added environmental hormones.
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KEYWORD
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Angelica gigas Nakai, decursin, cytotoxic activity, environmental hormones, apoptosis
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